Антиспермальные антитела (ASA) вырабатываются, когда гематотестикулярный барьер разрушается в результате обструкции, инфекции или травмы. Иммуноглобулины класса IgG обычно присутствуют как в сыворотке, так и в сперме, а антитела IgG прикрепляются к сперматозоидам. АСК класса IgA секретируются добавочными половыми железами и обнаруживаются только в сперме. АСК класса IgG могут быть обнаружены в семенной плазме, но свободный IgA в семенной плазме обычно отсутствует. Антиспермальные антитела класса IgA почти никогда не встречаются без антител IgG.

В случае, если более 40% подвижных сперматозоидов содержат АСК класса IgG, целесообразно дополнительное тестирование на антитела IgA.

Иммунологический фактор снижает вероятность спонтанного зачатия, особенно при наличии АСК класса IgA.

SpermMar Test IgG имеет срок годности 18 месяцев с даты производства. Информацию о составе продукта можно найти в паспорте безопасности материала.

Лицензирование

Европа: маркировка CE

США: зарегистрировано

Канада: лицензия Министерства здравоохранения Канады

Бразилия: зарегистрировано

Австралия: зарегистрировано

Узбекистан: разрешение Фармацевтического Коммитета РУз

Научные работы

Al-Dujaily S.S., Chakir W.K., Hantoosh S.F., Direct Antisperm Antibody Examination of Infertile Men, Global Journal of Medical Research (2012),Vol.12,No.3

Bohring C., Klepper L., Krause W., Localization of binding sites of naturally occurring antisperm antibodies on human spermatozoa by immunofluorescence, Andrologia (2004),Vol.36,pp.286-290

Bohring C., Krause E., Habermann B., Krause W., Isolation and identification of sperm membrane antigens recognized by antisperm antibodies, and their possible role in immunological infertility disease, Molecular Human Reproduction (2001),Vol.7,No.2,pp.113-118

Bohring C., Krause W., Characterization of Spermatozoa Surface Antigens by Antisperm Antibodies and its Influence on Acrosomal Exocytosis, American Journal of Reproductive Immunology (2003),Vol.50,pp.411-419

Bohring C., Krause W., The characterization of human spermatozoa membrane proteins – surface antigens and immunological infertility, Electrophoresis (1999),Vol.20,pp.971-976

Bohring C., Krause W., The intra- and inter-assay variation of the indirect mixed antiglobulin reaction test: is a quality control suitable?, Human Reproduction (1999),Vol.14,No.7,pp.1802-1805

Bozhedomov V.A., Nikolaeva M.A., Ushakova I.V., et al., Functional deficit of sperm and fertility impairment in men with antisperm antibodies , Journal of Reproductive Immunology (2015),Vol.112,pp.95-101

Chavez-Badiola A., Drakeley A.J., Finney V., et al., Necrospermia, antisperm antibodies, and vasectomy, Fertility and Sterility (2008),Vol.89,No.3,pp.723e5-e7

Chiu W.W-C., Chamley L.W., Human seminal plasma prolactin-inducible protein is an immunoglobulin G-binding protein, Journal of Reproductive Immunology (2003),Vol.60,pp.97-111

Depuydt C.E., Bosmans E., Zalata A., et al., The Relation Between Reactive Oxygen Species and Cytokines in Andrological Patients With or Without Male Accesory Gland Infection, Journal of Andrology (1996),Vol.17,No.6,pp.699-707

Depuydt C.E., De Potter C.R., Zalata A., et al., Levels of Hepatocyte Growth Factor/Scatter Factor (HGF/SF) in Seminal Plasma of Patients With Andrological Diseases, Journal of Andrology (1998),Vol.19,No.2,pp.175-182

Garolla A., Pizzol D., Bertoldo A., et al., Association, prevalence, and clearance of human papillomavirus and antisperm antibodies in infected semen samples from infertile patients, Fertility and Sterility (2013),Vol.99,No.1,pp.125-131

Gatimel N., Moreau J., Isus F., et al., Anti-sperm antibodies detection by a modified MAR test: Towards a better definition of its indications, Reproductive biomedicine online (2018),Vol.37,No.6,pp.717-723

Hadinedoushan H., Ghafourzadeh M., A survey of anti-sperm antibodies in infertile couples, Iranian Journal of Reproductive Medicine (2007),Vol.5,No.1,pp.39-40

Hussein T.M., Elneily D., Eid A.A., Abou-ElKhier H., Assessment of antisperm antibodies in a sample of Egyptian patients with hepatitis C virus infection, Andrologia (2017),Vol.49,No.e12664

Laudat A., Burc-Struxiano L., Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm Antigens?, Open Access Library Journal (2016),Vol.3,No.e2978

Lotti F., Baldi E., Corona G., et al., Epididymal more than testicular abnormalities are associated with the occurence of antisperm antibodies as evaluated by the MAR test, Human Reproduction (2018),Vol.33,No.8,pp.1417-1429

Marconi M., Nowotny A., Pantke P., et al., Antisperm antibodies detected by mixed agglutination reaction and immunobead test are not associated with chronic inflammation and infection of the seminal tract, Andrologia (2008),Vol.40,pp.227-234

Marconi M., Pilatz A., Wagenlehner F., et al., Are Antisperm Antibodies Really Associated with Proven Chronic Inflammatory and Infectious Diseases of the Male Reproductive Tract?, European Urology (2009),Vol.56,pp.708-715

Ombelet W., Vandeput H., Janssen M., et al., Treatment of male infertility due to sperm surface antibodies: IUI or IVF?, Human Reproduction (1997),Vol.12,No.6,pp.1165-1170

Poppe K., Glinoer D., Tournaye H., et al., Is systematic screening for thyroid disorders indicated in subfertile men?, European Journal of Endocrinology (2006),Vol.154,pp.363-366

Rossato M., Galeazzi C., Ferigo M., Foresta C., Antisperm antibodies modify plasma membrane functional integrity and inhibit osmosensitive calcium influx in human sperm, Human Reproduction (2004),Vol.19,No.8,pp.1816-1820

Tennakoon V., Weerasekera DS., Yasawardene SG., Successful pregnancy outcomes following in-vitro fertilization in infertile couples with high levels of antisperm antibodies, Sri Lanka Journal of Obstetrics and Gynaecology (2010),Vol.32,pp.47-48

Tennakoon V., Yasawardene S.G., Weerasekera D.S., Possible risk factors for the formation of antisperm antibodies in a subfertile population, Sri Lanka Journal of Obstetrics and Gynaecology (2011),Vol.33,pp.12-19

Verón G.L., Molina R.I., Tissera A.D., et al., Incidence of Sperm Surface Autoantibodies and Relationship with Routine Semen Parameters and Sperm Kinematics, Am J Reprod Immunol (2016),Vol.76,pp.59-69

Код продукции

SPMG_S : SpermMar Test IgG – Single kit – 50 tests